General Information

  • ID:  hor003406
  • Uniprot ID:  E9HBU8
  • Protein name:  Orcokinin 2
  • Gene name:  NA
  • Organism:  Daphnia pulex (Water flea)
  • Family:  Orcokinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Daphnia (genus), Daphniidae (family), Anomopoda (infraorder), Cladocera (suborder), Diplostraca (order), Phyllopoda (subclass), Branchiopoda (class), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  NA

Sequence Information

  • Sequence:  NLDEIDRSDFGRFV
  • Length:  14
  • Propeptide:  MNCLKFRLVAVAILIFNVVTALNYQSEEAVGVEHERDRDSLGGGHILRGLDSIGESNLLRAIYREKPRDFLRINRGLDSLSGASFGIEKRLDSLTGLGFGSQKRNLDEIDRSNFGTFAKRNLDEIDRSDFGRFVKKRETMEAESSQQQH
  • Signal peptide:  MNCLKFRLVAVAILIFNVVTA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myotropic
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-E9HBU8-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor003406_AF2.pdbhor003406_ESM.pdb

Physical Information

Mass: 191487 Formula: C73H111N21O25
Absent amino acids: ACHKMPQTWY Common amino acids: D
pI: 4.06 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 5
Hydrophobicity: -68.57 Boman Index: -5207
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 76.43
Instability Index: 4365.71 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  21830762
  • Title:  Genomics, Transcriptomics, and Peptidomics of Daphnia Pulex Neuropeptides and Protein Hormones